Endocrine Abstracts

The secretion of prolactin is sexually dimorphic and sensitive to changes in gonadal steroid and glucocorticoid status. Reports that the regulatory effects of glucocorticoids on prolactin release are mediated in part via annexin I (ANXA1, 1), have led us to compare prolactin secretion in ANXA1 knockout (KO) and wildtype (WT) mice and to determine the effects ovariectomy and oestrogen replacement (80 nanograms/0.1 ml, s.c./day) on (a) the plasma prolactin concentration (radioim...